Propargyl alcohol

1Identification

Name

Propargyl alcohol

IUPAC name

prop-2-yn-1-ol

CAS number

107-19-7 (also reported: 201740-99-0)

EC number

203-471-2

Molecular formula

C3H4O

Molecular weight

56.06 g/mol

InChIKey

TVDSBUOJIPERQY-UHFFFAOYSA-N

SMILES

C#CCO

PubChem CID

7859

Synonyms

PROPARGYL ALCOHOL, Prop-2-yn-1-ol, 2-Propyn-1-ol, 1-Propyn-3-ol, 2-Propynyl alcohol, Ethynylcarbinol, 2-Propynol, Ethynyl carbinol, Propynyl alcohol, Methanol, ethynyl-, 3-Propynol, 1-Hydroxy-2-propyne, 3-Hydroxy-1-propyne, Acetylenylcarbinol

Recommended uses

• Used in steel and chemical production; Also used as a solvent stabilizer, fumigant, and corrosion inhibitor; [ACGIH]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Steel Producing [Category: Industry] Semiconductor Manufacturing [Category: Industry] Farming (Pesticides) [Category: Industry]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Has been used to prevent hydrogen embrittlement of steel; as corrosion inhibitor; solvent stabilizer; soil fumigant /former/; chemical intermediate; lab reagent
  Hazardous Substances Data Bank (HSDB)
• Intermediate Processing aids not otherwise specified
  EPA Chemical Data Reporting (CDR)

Description

• Propargyl alcohol appears as a clear colorless liquid with a geranium-like odor. Flash point 97 °F. Vapors are heavier than air. Used to make other chemicals, as a corrosion inhibitor and a soil fumigant.
  CAMEO Chemicals
• Prop-2-yn-1-ol is a terminal acetylenic compound that is prop-2-yne substituted by a hydroxy group at position 1. It has a role as an antifungal agent and a Saccharomyces cerevisiae metabolite. It is a volatile organic compound, a propynol and a terminal acetylenic compound.
  ChEBI
• propargyl alcohol has been reported in Foeniculum vulgare with data available.
  LOTUS - the natural products occurrence database

2Hazard identification

Signal word

Danger

Pictograms

GHS02, GHS05, GHS06, GHS09

Classification source

Regulation (EC) No 1272/2008 of the European Parliament and of the Council

Precautionary statements

Other reported classifications

5 classification records exist across sources. Differences usually reflect purity, physical form or impurities.

NFPA 704 rating

• 4 - Materials that, under emergency conditions, can be lethal.
  Hazardous Substances Data Bank (HSDB)
• 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.
  Hazardous Substances Data Bank (HSDB)
• 3 - Materials that in themselves are capable of detonation or explosive decomposition or explosive reaction but that require a strong initiating source or must be heated under confinement before initiation.
  Hazardous Substances Data Bank (HSDB)

Health hazards

• Severe health hazard. Central nervous system depressant. May be fatal is absorbed through skin or inhaled. Causes severe irritation. High concentrations are extremely destructive to mucous membranes, upper respiratory tract, eyes and skin. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. (USCG, 1999)
  CAMEO Chemicals

Fire hazards

• Special Hazards of Combustion Products: Acrid smoke, fumes (USCG, 1999)
  CAMEO Chemicals
• Flammable. Above 33 °C explosive vapour/air mixtures may be formed.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Hazards summary

• Liquid causes second degree burns after contact for a few minutes. [CHRIS] Toxic to liver and kidneys in rats after repeated exposure to concentrations of 80 ppm; TLV Basis: Eye irritation and liver & kidney damage; A TLV–TWA of 1 ppm (2.3 mg/m3) is recommended for occupational exposure to propargyl alcohol, based on the structural and apparent toxicological similarity to allyl alcohol . . . [ACGIH] A lachrymator; [CHEMINFO] See Allyl alcohol.
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

• EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
  CAMEO Chemicals
• (General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention. Breathing: Respiratory support Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
  The National Institute for Occupational Safety and Health (NIOSH)

Symptoms of exposure

• Cough. Sore throat.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• MAY BE ABSORBED! Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Pain. Severe deep burns.
  ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

• Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance.
  Hazardous Substances Data Bank (HSDB)
• If material or fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Isolation and evacuation

• Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary. FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
  CAMEO Chemicals

Spill cleanup

• Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.
  Hazardous Substances Data Bank (HSDB)
• Eliminate all ignition sources. Stop or control the leak if this can be done without undue risk. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Absorb in noncombustible material for proper disposal.
  Hazardous Substances Data Bank (HSDB)

7Handling and storage

• Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Well closed.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Fireproof. Separated from strong oxidants, food and feedstuffs. Keep in the dark. Well closed.
  Hazardous Substances Data Bank (HSDB)
• Store in a cool, dry, well-ventilated location. Store away from heat, oxidizing materials, acids, alkalies, and sunlight.
  Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

Personal protective equipment

• Excerpt from NIOSH Pocket Guide for Propargyl alcohol: Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact. Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact. Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated. Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the workshift.
  CAMEO Chemicals
• Wear special protective clothing and positive pressure self-contained breathing apparatus.
  Hazardous Substances Data Bank (HSDB)
• The MSA type GMA chin style common organic vapor canister was tested against nine hazardous vapors in a controlled access laboratory under conditions similar to the most severe expected operating conditions in the field. The vapors tested included chloroform, benzene, epichlorohydrin, acrylonitrile, propargyl alcohol, 1,2-dibromoethane, acrolein, chloromethyl-methyl-ether, and N-nitrosodimethylamine. The challenge concentration was 50 times the assigned TLV or 50 times the lowest practical concentration where no TLV was assigned. A flow rate through the canisters corresponding to 49 standard l/min was used.
  Hazardous Substances Data Bank (HSDB)
• Wear appropriate personal protective clothing to prevent skin contact.
  Hazardous Substances Data Bank (HSDB)

Respirator recommendations

• Important additional information about respirator selection
  The National Institute for Occupational Safety and Health (NIOSH)

9Physical and chemical properties

10Stability and reactivity

Reactivity

• When phosphorus pentaoxide is added to PROPARGYL ALCOHOL, caused ignition. Acetyl bromide reacts violently with alcohols or water [Merck 11th ed. 1989]. Mixtures of alcohols with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. Example: An explosion will occur if dimethylbenzylcarbinol is added to 90% hydrogen peroxide then acidified with concentrated sulfuric acid. Mixtures of ethyl alcohol with concentrated hydrogen peroxide form powerful explosives. Mixtures of hydrogen peroxide and 1-phenyl-2-methyl propyl alcohol tend to explode if acidified with 70% sulfuric acid [Chem. Eng. News 45(43):73 1967]; [J. Org. Chem. 28:1893 1963].
  CAMEO Chemicals
• Highly flammable. Less dense than water and soluble in water.
  CAMEO Chemicals

Incompatible materials and hazardous reactions

• Addition of phosphorus pentoxide to propargyl alcohol caused the alcohol to burst into flame.
  Hazardous Substances Data Bank (HSDB)
• Phosphorus pentoxide, oxidizers.
  Hazardous Substances Data Bank (HSDB)
• If propargyl alcohol and similar acetylene compounds are dried with alkali before distillation, the residue may explode (probably owing to salt formation). Sodium sulfate is recommended as a suitable desiccant.
  Hazardous Substances Data Bank (HSDB)

11Toxicological information

Routes of exposure

• The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• inhalation, skin absorption, ingestion, skin and/or eye contact
  The National Institute for Occupational Safety and Health (NIOSH)

Target organs

• Hepatic Urinary
  EPA Integrated Risk Information System (IRIS)
• Skin, respiratory system, central nervous system, liver, kidneys
  The National Institute for Occupational Safety and Health (NIOSH)

Short-term exposure effects

• The substance is irritating to the eyes, skin and respiratory tract. The vapour is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the liver and kidneys. This may result in impaired functions. Exposure above the OEL could cause death. Medical observation is indicated.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Carcinogen classification

• Propargyl Alcohol
  NTP Technical Reports
• TR-552: Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (2008 )
  NTP Technical Reports
• 05/17/07
  NTP Technical Reports
• Some Evidence
  NTP Technical Reports

12Ecological information

Environmental fate

• Propargyl alcohol's production and use as a corrosion inhibitor, solvent stabilizer, and laboratory reagent may result in its release to the environment through various waste streams. Its former use as a soil fumigant would have resulted in its direct release to the environment. If released to air, an extrapolated vapor pressure of 15.6 mm Hg at 25 °C indicates propargyl alcohol will exist solely as a vapor in the atmosphere. Vapor-phase propargyl alcohol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 37 hours.
  Hazardous Substances Data Bank (HSDB)

Ecotoxicity

• LC50 Pimephales promelas (fathead minnow) 1.44 mg/l/96 hr (confidence limit 1.25-1.67 mg/l), flow-through bioassay with measured concentrations, 24.7 °C, dissolved oxygen 6.9 mg/l, hardness 42.8 mg/l calcium carbonate, alkalinity 40.6 mg/l calcium carbonate, and pH 7.7.
  Hazardous Substances Data Bank (HSDB)
• EC50 Pimephales promelas (fathead minnow) 1.44 mg/l/96 hr (confidence limit 1.25-1.67 mg/l), flow-through bioassay with measured concentrations, 24.7 °C, dissolved oxygen 6.9 mg/l, hardness 42.8 mg/l calcium carbonate, alkalinity 40.6 mg/l calcium carbonate, and pH 7.7. Effect: loss of equilibrium.
  Hazardous Substances Data Bank (HSDB)
• LC50 Pimephales promelas (fathead minnow) 1.53 mg/l/96 hr (confidence limit 1.49-1.56 mg/l), flow-through bioassay with measured concentrations, 25.7 °C, dissolved oxygen 6.8 mg/l, hardness 43.4 mg/l calcium carbonate, alkalinity 40.8 mg/l calcium carbonate, and pH 7.72.
  Hazardous Substances Data Bank (HSDB)

13Disposal considerations

• [40 CFR 240-280, 300-306, 702-799 (7/1/2006)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P102, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
  Hazardous Substances Data Bank (HSDB)
• A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.
  Hazardous Substances Data Bank (HSDB)

14Transport information

UN numbers: UN 1986, UN 2929

Shipping name

• NA 1986; Propargyl alcohol
  Hazardous Substances Data Bank (HSDB)
• UN 1986; Alcohols, flammable, toxic, NOS
  Hazardous Substances Data Bank (HSDB)

DOT label

• Flammable Liquid Poison
  CAMEO Chemicals

UN classification

• UN Hazard Class: 6.1; UN Subsidiary Risks: 3; UN Pack Group: II
  ILO-WHO International Chemical Safety Cards (ICSCs)

Emergency Response Guidebook

• 1986 131
  The National Institute for Occupational Safety and Health (NIOSH)

How DOT hazard classes work →

15Regulatory information

• Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
  Hazardous Substances Data Bank (HSDB)
• Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 2-Propyn-1-ol is included on this list.
  Hazardous Substances Data Bank (HSDB)
• P102; As stipulated in 40 CFR 261.33, when propargyl alcohol, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 7859 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.