Skip to content

Safety data summary

Phenol

Phenol (CAS 108-95-2) is a chemical substance with the molecular formula C6H6O and a molecular weight of 94.11 g/mol. Under the EU harmonised GHS classification (CLP Annex VI), it carries the signal word “Danger” and is classified as corrosive, acutely toxic, a suspected mutagen, and toxic to specific organs. Its label shows the Corrosion, Skull and Crossbones, and Health Hazard pictograms. Key hazard statements include H301 (toxic if swallowed), H311 (toxic in contact with skin), and H314 (causes severe skin burns and eye damage). The OSHA permissible exposure limit (PEL) is 5 ppm (19mg/m³).

Hazards at a glance

  • H301Toxic if swallowed
  • H311Toxic in contact with skin
  • H314Causes severe skin burns and eye damage
  • H331Toxic if inhaled
  • H341Suspected of causing genetic defects
  • H373May causes damage to organs through prolonged or repeated exposure

Regulation (EC) No 1272/2008 of the European Parliament and of the Council — harmonised classification (CLP Annex VI)

This is a reference summary, not a manufacturer SDS. Classifications differ between suppliers, concentrations and mixtures. Always use the SDS that came with your product. Have one you want explained? Upload it to the AI SDS analyzer.

1Identification

Name
Phenol
IUPAC name
phenol
CAS number
108-95-2
EC number
203-632-7
Molecular formula
C6H6O
Molecular weight
94.11 g/mol
InChIKey
ISWSIDIOOBJBQZ-UHFFFAOYSA-N
SMILES
C1=CC=C(C=C1)O
PubChem CID
996
Synonyms
phenol, carbolic acid, Hydroxybenzene, Phenic acid, Oxybenzene, Benzenol, Phenylic acid, Phenylic alcohol, Monophenol, Phenyl hydrate, Phenyl hydroxide, PhOH, Monohydroxybenzene, Paoscle

Recommended uses

  • The primary use of phenol is in the production of phenolic resins, which are used in the plywood, construction, automotive, and appliance industries. Other uses of phenol include as a slimicide, as a disinfectant, and in medicinal products such as ear and nose drops, throat lozenges, and mouthwashes.
    EPA Hazardous Air Pollutants
  • Used in organic synthesis and as a disinfectant; [ACGIH] Used mainly as an intermediate for chemicals and resins; Also used in cosmetics, medical preparations, non-agricultural biocides, adhesives, binders, impregnating agents, paints, lacquers, varnishes, solvents, flooring, hardeners, and insulating materials; [CPS&Q: RARs - Final Report] Used as a flavoring agent; [FDA] Other uses include reagent in chemical analysis, in germicidal paints and slimicides, as a preservative for pharmaceutical injections, and in human and veterinary medicine; [HSDB]
    Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Molding and Core Making [Category: Foundry] Painting (Pigments, Binders, and Biocides) [Category: Paint] Working with Glues and Adhesives [Category: Other] Using Disinfectants or Biocides [Category: Clean] Burning Synthetic Polymers [Category: Burn]
    Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Stabilizing agent Other Ion exchange agent Polymerization promoter Solvent Cleaning agent Abrasives Laboratory chemicals Fuel Fuel agents Intermediate Monomers
    EPA Chemical Data Reporting (CDR)
  • Other Binder Not Known or Reasonably Ascertainable Solvent Abrasives Intermediate
    EPA Chemical Data Reporting (CDR)

Use categories: Chemical Classes -> Phenols/phenoxy acids · Fragrance Ingredients · Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes · Flavoring Agents -> JECFA Flavorings Index

Description

  • Phenol is both a manufactured chemical and a natural substance. It is a colorless-to-white solid when pure. The commercial product is a liquid. Phenol has a distinct odor that is sickeningly sweet and tarry. You can taste and smell phenol at levels lower than those that are associated with harmful effects. Phenol evaporates more slowly than water, and a moderate amount can form a solution with water. Phenol can catch fire. Phenol is used primarily in the production of phenolic resins and in the manufacture of nylon and other synthetic fibers.
    Agency for Toxic Substances and Disease Registry (ATSDR)
  • Phenol solution, [aqueous] is a white crystalline mass dissolved in an aqueous solution. Solution may be colorless to slightly pink in color with a distinctive phenol odor; sharp burning taste. Aqueous solution will be acidic and act as such. Toxic by ingestion, inhalation and skin absorption; strong irritant to tissues.
    CAMEO Chemicals
  • Phenol, liquid appears as a colorless liquid when pure, otherwise pink or red. Combustible. Flash point 175 °F. Must be heated before ignition may occur easily. Vapors are heavier than air. Corrosive to skin but because of anesthetic qualities will numb rather than burn. Upon contact skin may turn white. May be lethal by skin absorption. Does not react with water. Stable in normal transportation. Reactive with various chemicals and may be corrosive to lead, aluminum and its alloys, certain plastics, and rubber. Freezing point about 105 °F. Density 8.9 lb / gal. Used to make plastics, adhesives and other chemicals.
    CAMEO Chemicals

2Hazard identification

Signal word
Danger
Pictograms
GHS05, GHS06, GHS08
Classification source
Regulation (EC) No 1272/2008 of the European Parliament and of the Council

Precautionary statements

CodeStatement
P203Obtain, read and follow all safety instructions before use.
P260Do not breathe dust/fume/gas/mist/vapors/spray.
P261Avoid breathing dust/fume/gas/mist/vapors/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands [and ...] thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P316IF SWALLOWED: Get emergency medical help immediately.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352IF ON SKIN: wash with plenty of water/...
P302+P361+P354IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes.
P304+P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P354+P338IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P316Get emergency medical help immediately.
P318if exposed or concerned, get medical advice.
P319Get medical help if you feel unwell.
P321Specific treatment (see ... on this label).
P330Rinse mouth.
P361+P364Take off immediately all contaminated clothing and wash it before reuse.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to ...

Other reported classifications

6 classification records exist across sources. Differences usually reflect purity, physical form or impurities.

SourceSignalHazard codes
European Chemicals Agency (ECHA)DangerH301, H311, H314, H318, H331, H341, H373, H411
NITE-CMCDangerH302, H311, H314, H318, H341, H360, H370, H372, H401, H411
NITE-CMC—H401, H412
NITE-CMCDangerH302, H311, H314, H318, H340, H360, H370, H372

NFPA 704 rating

  • 4 - Materials that, under emergency conditions, can be lethal.
    Hazardous Substances Data Bank (HSDB)
  • 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.
    Hazardous Substances Data Bank (HSDB)
  • 0 - Materials that in themselves are normally stable, even under fire conditions.
    Hazardous Substances Data Bank (HSDB)

Health hazards

  • Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death. Methyl bromoacetate (UN2643) is an eye irritant/lachrymator (causes flow of tears). Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024)
    CAMEO Chemicals
  • Will burn eyes and skin. The analgesic action may cause loss of pain sensation. Readily absorbed through skin, causing increased heart rate, convulsions, and death. (USCG, 1999)
    CAMEO Chemicals
  • Toxic hazard rating is very toxic: probable oral lethal dose (human) is 50-500 mg/kg. Ingestion of 1 gram has been lethal to humans. Lethal amounts may be absorbed through skin or inhaled. Industrial contact can cause chronic poisoning with kidney and liver damage. Persons affected with hepatic or kidney diseases are at a greater risk. (EPA, 1998)
    CAMEO Chemicals

Fire hazards

  • Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Corrosives in contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2024)
    CAMEO Chemicals
  • Special Hazards of Combustion Products: Unburned vapor is toxic Behavior in Fire: Yields flammable vapors when heated, which will form explosive mixtures with air (USCG, 1999)
    CAMEO Chemicals
  • Flammable vapors when heated. Runoff from fire control water may give off poisonous gases and cause pollution. Mixtures of 9-10% phenol in air are explosive. Avoid aluminum chloride/nitrobenzene mixture, peroxodisulfuric acid, peroxomonosulfuric acid and strong oxidizing agents. Decomposes slowly on air contact. Avoid contact with strong oxidizing agents. (EPA, 1998)
    CAMEO Chemicals

Hazards summary

  • Phenol is both a manufactured chemical and a natural substance. It is a colorless-to-white solid when pure. The commercial product is a liquid. Phenol has a distinct odor that is sickeningly sweet and tarry. You can taste and smell phenol at levels lower than those that are associated with harmful effects. Phenol evaporates more slowly than water, and a moderate amount can form a solution with water. Phenol can catch fire. Phenol is used primarily in the production of phenolic resins and in the manufacture of nylon and other synthetic fibers.
    Agency for Toxic Substances and Disease Registry (ATSDR)
  • Exposure to phenol may occur from the use of some medicinal products (including throat lozenges and ointments). Phenol is highly irritating to the skin, eyes, and mucous membranes in humans after acute (short-term) inhalation or dermal exposures. Phenol is considered to be quite toxic to humans via oral exposure. Anorexia, progressive weight loss, diarrhea, vertigo, salivation, a dark coloration of the urine, and blood and liver effects have been reported in chronically (long-term) exposed humans. Animal studies have reported reduced fetal body weights, growth retardation, and abnormal development in the offspring of animals exposed to phenol by the oral route.
    EPA Hazardous Air Pollutants

3Composition / information on ingredients

SubstanceCASECFormula
Phenol108-95-2203-632-7C6H6O

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

  • Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. Removal of solidified molten material from skin requires medical assistance. (ERG, 2024)
    CAMEO Chemicals
  • EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
    CAMEO Chemicals
  • Excerpt from NIOSH Pocket Guide for Phenol: Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: SOAP WASH IMMEDIATELY - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly. Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once.
    CAMEO Chemicals
  • Signs and Symptoms of Acute Phenol Exposure: Signs and symptoms of acute exposure to phenol may be severe, and range from tachycardia (rapid heart rate) and tachypnea (rapid respiratory rate) to hypotension (low blood pressure), weak pulse, cardiac failure, pulmonary edema, and respiratory arrest. Cardiac arrhythmias may be noted. Weakness, headache, dizziness, tinnitus (ringing in the ears), delirium, and shock are common. Seizures may often be followed by coma. Pallor, profuse sweating, dilated pupils, and a profound drop in body temperature may occur. Gastrointestinal effects may include nausea, abdominal pain, bloody vomitus, and bloody diarrhea.
    CAMEO Chemicals

Symptoms of exposure

  • Sore throat. Burning sensation. Cough. Dizziness. Headache. Shortness of breath. Laboured breathing. Unconsciousness. Symptoms may be delayed.
    ILO-WHO International Chemical Safety Cards (ICSCs)
  • MAY BE ABSORBED! Serious skin burns. Numbness. Convulsions. Collapse. Unconsciousness.
    ILO-WHO International Chemical Safety Cards (ICSCs)
  • Pain. Redness. Loss of vision. Severe burns.
    ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

  • If material on fire or involved in fire: Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run off-water out of sewers and water sources. /Phenol, solid/
    Hazardous Substances Data Bank (HSDB)
  • If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water as flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources. /Phenol, molten/
    Hazardous Substances Data Bank (HSDB)
  • To fight fire, use alcohol foam, carbon dioxide or dry chemical.
    Hazardous Substances Data Bank (HSDB)

Hazardous combustion products

  • Toxic and irritating vapors are generated when heated.
    Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Isolation and evacuation

  • Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary. FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
    CAMEO Chemicals
  • Immediate precautionary measure · Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Spill · For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances. · For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary. Fire · If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
    Emergency Response Guidebook (ERG)

Spill cleanup

  • Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
    ILO-WHO International Chemical Safety Cards (ICSCs)
  • Control runoff and isolate discharged material for proper disposal. Approach release from upwind.
    Hazardous Substances Data Bank (HSDB)
  • Phenolic cmpd in wastewater are oxidized with hydrogen peroxide catalyzed by Fe+3-Fe+2. When the wt ratio of PhOH:H2O2 is 1:3 and iron 5-100 ppm, more than 95% of the phenols are removed in 30 min from a 500 ppm phenol soln at pH 5-6 and 25-50 °C.
    Hazardous Substances Data Bank (HSDB)
  • Spills must be disposed of immediately by properly protected personnel; no other person should remain in the area. Flush with flooding quantities of water, then use caustic soda soln for neutralization.
    Hazardous Substances Data Bank (HSDB)

7Handling and storage

  • Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Dry. Well closed. Store only in original container. Keep in a well-ventilated room. Store in an area without drain or sewer access.
    ILO-WHO International Chemical Safety Cards (ICSCs)
  • Phenol should be stored in closed containers in an area which is adequate to ensure that airborne phenol concentrations do not exceed 20 mg/cu m. Conditions shall be controlled to prevent overheating and the buildup of pressure in phenol containers. Storage tanks must be electrically grounded and bonded to transfer lines. Transfer and storage systems shall be designed and operated to prevent blockage by condensed phenol. Open flames are prohibited when drums of phenol are heated to melt the contents. The internal pressure will be vented by placing the drums with the bung up and the bung loosened. The bungs shall be tightened prior to moving or handling drums.
    Hazardous Substances Data Bank (HSDB)
  • Keep well closed and protected from light.
    Hazardous Substances Data Bank (HSDB)
  • Store in a cool, dry, well-ventilated location. Separate from oxidizers and acute fire hazards.
    Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

LimitValueSource
OSHA PEL5.0 [ppm]Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
OSHA PEL5 ppm (19mg/m³)Occupational Safety and Health Administration (OSHA)
NIOSH REL5 ppm (19 mg/m³)Occupational Safety and Health Administration (OSHA)
NIOSH REL15.6 ppm (60 mg/m³) [15 minutes]Occupational Safety and Health Administration (OSHA)
ACGIH TLV5.0 [ppm]Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
ACGIH TLV8 hr Time Weighted Avg (TWA) 5 ppm, skinHazardous Substances Data Bank (HSDB)
IDLH250 ppm [From NPG: Phenol] (NIOSH, 2024)CAMEO Chemicals
IDLH250 ppm (NIOSH, 2024)CAMEO Chemicals

Personal protective equipment

  • Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)
    CAMEO Chemicals
  • Fresh air mask for confined areas; rubber gloves; protective clothing; full face shield (USCG, 1999)
    CAMEO Chemicals
  • Excerpt from NIOSH Pocket Guide for Phenol: Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact. Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact. Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated. Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
    CAMEO Chemicals
  • When working with phenol, workers should be provided with and required to use protective clothing, gloves, face shields, splash -proof safty goggles and other appropriate protective clothing necessary to prevent any possibility of skin or eye contact with solid or liquid phenol or liquids containing phenol.
    Hazardous Substances Data Bank (HSDB)

Respirator recommendations

  • NIOSH/OSHA Up to 50 ppm: (APF = 10) Any air-purifying half-mask respirator with organic vapor cartridge(s) in combination with an N95, R95, or P95 filter. The following filters may also be used: N99, R99, P99, N100, R100, P100. Click here for information on selection of N, R, or P filters. (APF = 10) Any supplied-air respirator Up to 125 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode (APF = 25) Any powered, air-purifying respirator with an organic vapor cartridge in combination with a high-efficiency particulate filter.
    The National Institute for Occupational Safety and Health (NIOSH)

9Physical and chemical properties

Molecular weight94.11 g/mol
Physical description
Phenol solution, [aqueous] is a white crystalline mass dissolved in an aqueous solution. Solution may be colorless to slightly pink in color with a distinctive phenol odor; sharp burning taste. Aqueous solution will be acidic and act as such. Toxic by ingestion, inhalation and skin absorption; strong irritant to tissues. CAMEO Chemicals
Phenol, liquid appears as a colorless liquid when pure, otherwise pink or red. Combustible. Flash point 175 °F. Must be heated before ignition may occur easily. Vapors are heavier than air. Corrosive to skin but because of anesthetic qualities will numb rather than burn. Upon contact skin may turn white. May be lethal by skin absorption. Does not react with water. Stable in normal transportation. Reactive with various chemicals and may be corrosive to lead, aluminum and its alloys, certain plastics, and rubber. Freezing point about 105 °F. Density 8.9 lb / gal. Used to make plastics, adhesives and other chemicals. CAMEO Chemicals
Color / form
Colorless acicular crystals or white, crystalline mass Hazardous Substances Data Bank (HSDB)
White crystalline mass of hygroscopic, translucent needle-shaped crystals; pink or red when impurities are present; darkens on exposure to light Hazardous Substances Data Bank (HSDB)
Odor
Distinct aromatic, somewhat sickening sweet and acrid odor, discernable at 0.5 to 5 ppm Hazardous Substances Data Bank (HSDB)
Sweet, tarry odor Hazardous Substances Data Bank (HSDB)
Boiling point
360 °F at 760 mmHg (NTP, 1992) CAMEO Chemicals
359 °F at 760 mmHg (NIOSH, 2024) CAMEO Chemicals
359.1 °F at 760 mmHg (EPA, 1998) CAMEO Chemicals
Melting point
109 °F (NTP, 1992) CAMEO Chemicals
109 °F (NIOSH, 2024) CAMEO Chemicals
109 °F (EPA, 1998) CAMEO Chemicals
Flash point
175 °F (NTP, 1992) CAMEO Chemicals
175 °F (NIOSH, 2024) CAMEO Chemicals
174.2 °F (EPA, 1998) CAMEO Chemicals
Autoignition temperature
1319 °F (USCG, 1999) CAMEO Chemicals
1319 °F (715 °C) Hazardous Substances Data Bank (HSDB)
Density / specific gravity
1.04 at 105.8 °F (USCG, 1999) - Denser than water; will sink CAMEO Chemicals
1.06 (NIOSH, 2024) - Denser than water; will sink CAMEO Chemicals
Vapor density
3.24 (NTP, 1992) - Heavier than air; will sink (Relative to Air) CAMEO Chemicals
3.24 (EPA, 1998) - Heavier than air; will sink (Relative to Air) CAMEO Chemicals
Vapor pressure
0.2 mmHg at 68 °F ; 0.35 mmHg at 77 °F (NTP, 1992) CAMEO Chemicals
0.4 mmHg (NIOSH, 2024) CAMEO Chemicals
Solubility
50 to 100 mg/mL at 66 °F (NTP, 1992) CAMEO Chemicals
9 % at 77 °F (NIOSH, 2024) CAMEO Chemicals
82800 mg/L (at 25 °C) DrugBank
log Kow (LogP)
1.46 DrugBank
Log Kow = 1.46 Hazardous Substances Data Bank (HSDB)
Viscosity
3.437 mPa s @ 50 °C; 1.784 mPa s @ 75 °C; 1.099 mPa s @ 100 °C Hazardous Substances Data Bank (HSDB)
Odor threshold
Odor Threshold Low: 0.0045 [ppm] Odor Threshold High: 1.0 [ppm] Detection odor threshold from AIHA (mean = 0.060 ppm) Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
pH
about 6.0 (aq soln) Hazardous Substances Data Bank (HSDB)
Decomposition
When heated to decomposition it emits acrid smoke and irritating fumes. Hazardous Substances Data Bank (HSDB)
Explosive / flammable limits
1.7 % (NTP, 1992) CAMEO Chemicals
1.8 % (NIOSH, 2024) CAMEO Chemicals
8.6 % (NTP, 1992) CAMEO Chemicals
8.6 % (NIOSH, 2024) CAMEO Chemicals
1.7%-8.6% IN AIR Hazardous Substances Data Bank (HSDB)

10Stability and reactivity

Reactivity

  • Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound.
    CAMEO Chemicals
  • A liquid containing over 50% phenol. See Phenol (solid). Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound.
    CAMEO Chemicals
  • Water soluble.
    CAMEO Chemicals

Incompatible materials and hazardous reactions

  • Addition of aluminum chloride to a large volume of recovered nitrobenzene containing 5% phenol caused a violent explosion. Experiment showed that mixtures containing all three components reacted violently at 120 °C.
    Hazardous Substances Data Bank (HSDB)
  • Uncontrolled contact of phenol with peroxodisulfuric acid may cause explosion.
    Hazardous Substances Data Bank (HSDB)
  • /A combination of phenol with calcium hypochlorite/ ... is an exothermic reaction producing toxic fumes, which may ignite.
    Hazardous Substances Data Bank (HSDB)

Chemical stability

  • Prone to redden on exposure to air and light, hastened by presence of alkalinity.
    Hazardous Substances Data Bank (HSDB)

11Toxicological information

Target organs

  • Body Weight, Dermal (Skin), Hepatic (Liver), Renal (Urinary System or Kidneys), Respiratory (From the Nose to the Lungs)
    Agency for Toxic Substances and Disease Registry (ATSDR)
  • Eyes, skin, respiratory system, liver, kidneys
    The National Institute for Occupational Safety and Health (NIOSH)

Short-term exposure effects

  • The substance and the vapour are corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. The substance may cause effects on the central nervous system, heart and kidneys. This may result in convulsions, coma, cardiac disorders, respiratory failure and collapse. The effects may be delayed. Medical observation is indicated. Exposure could cause death.
    ILO-WHO International Chemical Safety Cards (ICSCs)

Long-term exposure effects

  • The substance may have effects on the liver, kidneys and nervous system.
    ILO-WHO International Chemical Safety Cards (ICSCs)

12Ecological information

Not available in the public sources we compile. Check Section 12 of the supplier's SDS.

13Disposal considerations

  • Incineration is the recommended method of disposal. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner or scrubber.
    Hazardous Substances Data Bank (HSDB)
  • Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U188, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
    Hazardous Substances Data Bank (HSDB)
  • Waste liquor containing 50,000 ppm was adjusted to give effluent containing 1 ppm then treated with activated sludge to give final effluent containing 0.07 ppm, 10% of which was recycled to conditioning tank.
    Hazardous Substances Data Bank (HSDB)

14Transport information

UN numbers: UN 1671, UN 2312, UN 2821

Shipping name

  • UN 1671; Phenol, solid
    Hazardous Substances Data Bank (HSDB)
  • UN 2312; Phenol, molten
    Hazardous Substances Data Bank (HSDB)

DOT hazard class

  • Phenol, molten
    US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172
  • UN2312
    US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172
  • Div 6.1 Poisonous materials (49 eCFR § 173.132)
    US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172

DOT label

  • Poison
    CAMEO Chemicals

UN classification

  • UN Hazard Class: 6.1; UN Pack Group: II
    ILO-WHO International Chemical Safety Cards (ICSCs)

Emergency Response Guidebook

  • 1671 153
    Emergency Response Guidebook (ERG)
  • 2312 153
    Emergency Response Guidebook (ERG)

How DOT hazard classes work →

15Regulatory information

  • This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Phenol is produced, as an intermediate or final product, by process units covered under this subpart.
    Hazardous Substances Data Bank (HSDB)
  • As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996.
    Hazardous Substances Data Bank (HSDB)
  • Phenol is exempted from the requirement of a tolerance when used as a solvent or cosolvent in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.
    Hazardous Substances Data Bank (HSDB)
  • Criterion (permissible level) for ambient water= 0.3 mg phenol/l.
    Hazardous Substances Data Bank (HSDB)
  • The criterion (permissible level) for protection of freshwater aquatic life is 600 ug/l (24 hr avg) and a ceiling of 3,400 ug/l.
    Hazardous Substances Data Bank (HSDB)
  • Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
    Hazardous Substances Data Bank (HSDB)
  • Pursuant to section 8(d) of TSCA, EPA promulagated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Phenol is included on this list.
    Hazardous Substances Data Bank (HSDB)
  • U188; As stipulated in 40 CFR 261.33, when phenol, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).
    Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 996 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.

Frequently asked questions about Phenol

What is the CAS number for Phenol?

The CAS Registry Number for Phenol is 108-95-2. Its EC (EINECS) number is 203-632-7. It is transported under UN 1671 / UN 2312 / UN 2821.

Is Phenol hazardous?

Yes. Phenol is classified under GHS with the signal word “Danger”. Hazard statements: H301: Toxic if swallowed; H311: Toxic in contact with skin; H314: Causes severe skin burns and eye damage; H331: Toxic if inhaled; H341: Suspected of causing genetic defects; H373: May causes damage to organs through prolonged or repeated exposure.

Is Phenol flammable?

Phenol is not classified as flammable under its primary GHS classification, but a flash point of 175 °F (NTP, 1992) has been reported, so it can burn under some conditions.

Which GHS pictograms apply to Phenol?

Phenol labels carry GHS05 (Corrosion), GHS06 (Skull and Crossbones), and GHS08 (Health Hazard).

What are the workplace exposure limits for Phenol?

OSHA PEL: 5 ppm (19mg/m³). NIOSH REL: 5 ppm (19 mg/m³). ACGIH TLV: 8 hr Time Weighted Avg (TWA) 5 ppm, skin. IDLH: 250 ppm [From NPG: Phenol] (NIOSH, 2024).

What PPE is needed when handling Phenol?

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

What is the first aid for Phenol exposure?

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. Removal of solidified molten material from skin requires medical assistance. (ERG, 2024)

How should Phenol be stored?

Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Dry. Well closed. Store only in original container. Keep in a well-ventilated room. Store in an area without drain or sewer access.