Cyclohexanol

1Identification

Name

Cyclohexanol

IUPAC name

cyclohexanol

CAS number

108-93-0

EC number

203-630-6

Molecular formula

C6H12O

Molecular weight

100.16 g/mol

InChIKey

HPXRVTGHNJAIIH-UHFFFAOYSA-N

SMILES

C1CCC(CC1)O

PubChem CID

7966

Synonyms

Cyclohexyl alcohol, 1-Cyclohexanol, Hexahydrophenol, Hydrophenol, Hydroxycyclohexane, Hexalin, Adronal, Hydralin, Naxol, Adronol, Anol, Cicloesanolo, Cykloheksanol, Phenol, hexahydro-

Recommended uses

• Used in the production of nylon, paints, plastics, detergents, textiles, and pesticides; [ACGIH]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Textiles (Fiber & Fabric Manufacturing) [Category: Industry] Painting (Solvents) [Category: Paint]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Solvent for alkyd resins, alcohol-soluble phenolic resins, ethyl cellulose. Manufacture of celluloid; finishing textiles; in insecticides.
  Hazardous Substances Data Bank (HSDB)
• Dispersing agent Solvent Processing aids not otherwise specified Diluent Cleaning agent Intermediate
  EPA Chemical Data Reporting (CDR)
• Cleaning agent Solvent Dispersing agent
  EPA Chemical Data Reporting (CDR)

Use categories: Fragrance Ingredients · Insecticides

Description

• Cyclohexanol appears as a colorless liquid with a camphor-like odor. Soluble in most organic liquids. Flash point 154 °F. May be toxic by inhalation or skin exposure. Vapors are narcotic in high concentrations. Irritates skin, eyes and mucus membranes. Used in making soap, lacquers, and plastics.
  CAMEO Chemicals
• Cyclohexanol is an alcohol that consists of cyclohexane bearing a single hydroxy substituent. The parent of the class of cyclohexanols. It has a role as a solvent. It is a member of cyclohexanols and a secondary alcohol.
  ChEBI
• anol has been reported in Solidago odora, Cardiocrinum cordatum, and Osmorhiza aristata with data available.
  LOTUS - the natural products occurrence database

2Hazard identification

Signal word

Warning

Pictograms

GHS07

Classification source

Regulation (EC) No 1272/2008 of the European Parliament and of the Council

Precautionary statements

Other reported classifications

5 classification records exist across sources. Differences usually reflect purity, physical form or impurities.

NFPA 704 rating

• 1 - Materials that, under emergency conditions, can cause significant irritation.
  Hazardous Substances Data Bank (HSDB)
• 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.
  Hazardous Substances Data Bank (HSDB)
• 0 - Materials that in themselves are normally stable, even under fire conditions.
  Hazardous Substances Data Bank (HSDB)

Health hazards

• Narcosis-depression of the central nervous system tending to produce sleep or unconsciousness. (USCG, 1999)
  CAMEO Chemicals

Fire hazards

• Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. CAUTION: Methanol (UN1230) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.) Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.
  CAMEO Chemicals
• Combustible. Above 68 °C explosive vapour/air mixtures may be formed.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Hazards summary

• Liquid or solid form causes first degree burns on short exposure; [CHRIS] Skin absorption and narcosis seen in acute animal studies; [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC] Causes liver and kidney injury in high-dose animal studies; [HSDB]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

• EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
  CAMEO Chemicals
• (General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Water wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with water. If irritation persists after washing, get medical attention. Breathing: Respiratory support Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
  The National Institute for Occupational Safety and Health (NIOSH)

Symptoms of exposure

• Cough. Dizziness. Drowsiness. Headache. Nausea. Sore throat.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Dry skin. Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Redness. Pain.
  ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

• Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers.
  Hazardous Substances Data Bank (HSDB)
• If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical.
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Isolation and evacuation

• Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary. FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
  CAMEO Chemicals

Spill cleanup

• Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal.
  Hazardous Substances Data Bank (HSDB)
• Spill handling: evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, or a similar material and deposit in sealed containers. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.
  Hazardous Substances Data Bank (HSDB)
• Collect leaking and spilled liquid in sealable containers as far as possible. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
  Hazardous Substances Data Bank (HSDB)

7Handling and storage

• Separated from strong oxidants. Dry.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Cyclohexanol must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine), since violent reactions occur. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical.
  Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

Personal protective equipment

• Excerpt from NIOSH Pocket Guide for Cyclohexanol: Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact. Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact. Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated. Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. (NIOSH, 2024)
  CAMEO Chemicals
• Wear appropriate personal protective clothing to prevent skin contact.
  Hazardous Substances Data Bank (HSDB)
• Wear appropriate eye protection to prevent eye contact.
  Hazardous Substances Data Bank (HSDB)
• Personal protection: filter respirator for organic gases and vapors adapted to the airborne concentration of the substance.
  Hazardous Substances Data Bank (HSDB)

Respirator recommendations

• NIOSH/OSHA Up to 400 ppm: (APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)* (APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)* (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister (APF = 10) Any supplied-air respirator* (APF = 50) Any self-contained breathing apparatus with a full facepiece Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode (APF = 10,000) Any supplied-air respirator tha…
  The National Institute for Occupational Safety and Health (NIOSH)

9Physical and chemical properties

10Stability and reactivity

Reactivity

• CYCLOHEXANOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. Violent reaction with nitric acid. Incompatible with strong oxidizers (chromium trioxide, nitric acid, etc.). (NTP, 1992)
  CAMEO Chemicals
• Less dense than water and slightly soluble in water.
  CAMEO Chemicals

Incompatible materials and hazardous reactions

• Contact with strong oxidizers causes a fire and explosion hazard. Attacks some plastics.
  Hazardous Substances Data Bank (HSDB)
• Ignites on contact with chromium trioxide. Violent reaction with /nitric acid/. Incompatible with oxidants.
  Hazardous Substances Data Bank (HSDB)
• Strong oxidizers (such as hydrogen peroxide & nitric acid)
  The National Institute for Occupational Safety and Health (NIOSH)

11Toxicological information

Routes of exposure

• The substance can be absorbed into the body by inhalation and by ingestion.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• inhalation, skin absorption, ingestion, skin and/or eye contact
  The National Institute for Occupational Safety and Health (NIOSH)

Target organs

• Eyes, skin, respiratory system
  The National Institute for Occupational Safety and Health (NIOSH)

Short-term exposure effects

• The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Long-term exposure effects

• The substance defats the skin, which may cause dryness or cracking.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Carcinogen classification

• No indication of carcinogenicity to humans (not listed by IARC).
  Toxin and Toxin Target Database (T3DB)

12Ecological information

Environmental fate

• Cyclohexanol's production and use as in the synthesis of adipic acid, caprolactam (with cyclohexanone); as a stabilizer and homogenizer for soaps and synthetic detergent emulsions; as a solvent for lacquers, varnishes, oils, and shellacs, phenolic insecticides, for alkyd and phenolic resins, cellulosics; as a blending agent for lacquers, paints and varnishes; in finish removers, leather degreasing, polishing, plasticizers, plastics, and germicides may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 0.657 mm Hg at 25 °C indicates cyclohexanol will exist solely in the vapor phase in the atmosphere.
  Hazardous Substances Data Bank (HSDB)

Ecotoxicity

• LC50; Species: Lepomis macrochirus; Conditions: freshwater, static, 23 °C, mild aeration applied after 24 hr; Concentration: 1100 ppm for 96 hr
  Hazardous Substances Data Bank (HSDB)
• LC50; Species: Menidia beryllina; Conditions: synthetic seawater, static, 23 °C, mild aeration applied after 24 hr; Concentration: 720 ppm for 96 hr
  Hazardous Substances Data Bank (HSDB)
• LC50; Species: Pimephales promelas (fathead minnow); Conditions: Lake Superior water, static, 18-22 °C; Concentration: 1033 mg/L for 96 hr
  Hazardous Substances Data Bank (HSDB)

13Disposal considerations

• SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.
  Hazardous Substances Data Bank (HSDB)

14Transport information

UN numbers: UN 1986, UN 1993

DOT label

• Flammable Liquid Poison
  CAMEO Chemicals

Emergency Response Guidebook

• 1993 128(combustible liquid, n.o.s.)
  The National Institute for Occupational Safety and Health (NIOSH)

How DOT hazard classes work →

15Regulatory information

• This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Cyclohexanol is produced, as an intermediate or final product, by process units covered under this subpart.
  Hazardous Substances Data Bank (HSDB)
• Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 8/4/95; Reporting date: 10/3/95.
  Hazardous Substances Data Bank (HSDB)
• Cyclohexanol is an indirect food additive for use only as a component of adhesives.
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 7966 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.