Bisphenol A

1Identification

Name

Bisphenol A

IUPAC name

4-[2-(4-hydroxyphenyl)propan-2-yl]phenol

CAS number

80-05-7

EC number

201-245-8

Molecular formula

C15H16O2

Molecular weight

228.29 g/mol

InChIKey

IISBACLAFKSPIT-UHFFFAOYSA-N

SMILES

CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O

PubChem CID

6623

Synonyms

Bisphenol A, 2,2-Bis(4-hydroxyphenyl)propane, Bisphenol, Diano, 4,4'-Isopropylidenediphenol, 4,4'-(propane-2,2-diyl)diphenol, Diphenylolpropane, 4,4'-Bisphenol A, 2,2-Bis(p-hydroxyphenyl)propane, Parabis A, DIAN, Rikabanol, Bisphenol-A, Biphenol A

Recommended uses

• Used as a chemical intermediate, mainly for epoxy resins and polycarbonate resins; [HSDB] Used with epichlorohydrin to produce epoxy resins; [Kanerva, p. 1759]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Semiconductor Manufacturing [Category: Industry] Plastic Composites Manufacturing [Category: Industry] Welding Over Coatings [Category: Weld]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• The largest use for bisphenol A is polycarbonate ... followed by epoxy resins. Other uses are flame retardants, unsaturated polyester resins and polyacrylate, polyetherimide, and polysulfone resins.
  Hazardous Substances Data Bank (HSDB)
• Hydraulic fluids Flame retardant Filler Not Known or Reasonably Ascertainable Hardener Intermediate Heat stabilizer Surface modifier Solvent Binder Other Monomers
  EPA Chemical Data Reporting (CDR)
• Hydraulic fluids Not Known or Reasonably Ascertainable Intermediate Hardener Binder Monomers
  EPA Chemical Data Reporting (CDR)

Description

• Bisphenol A (BPA) can cause developmental toxicity according to The National Toxicology Program's Center for the Evaluation of Risks to Human Reproduction. It can cause female reproductive toxicity according to an independent committee of scientific and health experts.
  California Office of Environmental Health Hazard Assessment (OEHHA)
• 4,4'-isopropylidenediphenol appears as white to light brown flakes or powder. Has a weak medicine odor. Sinks in water. (USCG, 1999)
  CAMEO Chemicals
• Bisphenol A is a bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups. It has a role as an endocrine disruptor, a xenobiotic, a xenoestrogen and an environmental contaminant.
  ChEBI

2Hazard identification

Signal word

Danger

Pictograms

GHS05, GHS07, GHS08, GHS09

Classification source

Regulation (EC) No 1272/2008 of the European Parliament and of the Council

Precautionary statements

Other reported classifications

6 classification records exist across sources. Differences usually reflect purity, physical form or impurities.

Health hazards

• Dusts irritating to upper respiratory passages; may cause sneezing. (USCG, 1999)
  CAMEO Chemicals

Fire hazards

• This chemical is combustible. This compound may form explosive dust clouds. Static electricity can cause its dust to explode. (NTP, 1992)
  CAMEO Chemicals
• Combustible. Finely dispersed particles form explosive mixtures in air.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Hazards summary

• A skin, eye, and respiratory tract irritant; Repeated or prolonged contact may cause skin sensitization. [ICSC] Reports of sensitization are rare; A possible sensitizer in vinyl gloves; [Kanerva, p. 1759] Danger of photo-contact sensitization; [MAK]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

• EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
  CAMEO Chemicals

Symptoms of exposure

• Cough. Sore throat.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Redness. Pain.
  ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

• Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Hazardous Substances Data Bank (HSDB)
• Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
  Hazardous Substances Data Bank (HSDB)
• Use water spray, foam, powder, carbon dioxide.
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Isolation and evacuation

• Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary. FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
  CAMEO Chemicals

Spill cleanup

• Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
  Hazardous Substances Data Bank (HSDB)
• Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Vacuum cleaning is preferable to sweeping to keep dust levels down. Use special HEPA vacuum, not a shop vacuum. Ventilate area of spill or leak after cleanup is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.
  Hazardous Substances Data Bank (HSDB)

7Handling and storage

• Separated from acid anhydrides, acid chlorides, strong oxidants, strong bases and food and feedstuffs. Store in an area without drain or sewer access.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Keep container tightly closed in a dry and well-ventilated place.
  Hazardous Substances Data Bank (HSDB)
• Safe Storage: Separated from acid anhydrides, acid chlorides, strong oxidants, strong bases and food and feedstuffs. Store in an area without drain or sewer access.
  Hazardous Substances Data Bank (HSDB)
• Store away from heat and strong oxidizers ... .
  Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

No occupational exposure limits found in our sources.

Personal protective equipment

• Approved dust mask and clean, body-covering clothing sufficient to prevent excessive or repeated exposure to dust, fumes, or solutions. Safety glasses with side shields. (USCG, 1999)
  CAMEO Chemicals
• Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
  Hazardous Substances Data Bank (HSDB)
• Skin protection: Handle with gloves.
  Hazardous Substances Data Bank (HSDB)
• Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
  Hazardous Substances Data Bank (HSDB)

9Physical and chemical properties

10Stability and reactivity

Reactivity

• 4,4'-ISOPROPYLIDENEDIPHENOL is incompatible with strong oxidizers. It is also incompatible with strong bases, acid chlorides and acid anhydrides. (NTP, 1992)
  CAMEO Chemicals
• The finely powdered resin is a significant dust explosion hazard. Insoluble in water.
  CAMEO Chemicals

Incompatible materials and hazardous reactions

• Incompatible materials: Strong oxidizing agents.
  Hazardous Substances Data Bank (HSDB)
• Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts vigorously with acid anhydrides, acid chlorides and strong bases. This generates heat and pressure-rise explosion hazard.
  Hazardous Substances Data Bank (HSDB)
• Strong oxidizers, strong bases, acid chlorides, and acid anhydrides.
  Hazardous Substances Data Bank (HSDB)

Chemical stability

• Stable under recommended storage conditions.
  Hazardous Substances Data Bank (HSDB)

11Toxicological information

Short-term exposure effects

• The substance is severely irritating to the eyes. The substance is mildly irritating to the respiratory tract.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Long-term exposure effects

• Repeated or prolonged contact may cause skin sensitization and photosensitization. The substance may have effects on the upper respiratory tract. Ingestion may cause effects on the liver and kidneys. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
  ILO-WHO International Chemical Safety Cards (ICSCs)

12Ecological information

Not available in the public sources we compile. Check Section 12 of the supplier's SDS.

13Disposal considerations

• SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
  Hazardous Substances Data Bank (HSDB)
• Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.
  Hazardous Substances Data Bank (HSDB)
• Spillage Disposal: Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
  Hazardous Substances Data Bank (HSDB)

14Transport information

DOT label

• Class 9
  CAMEO Chemicals

Not available in the public sources we compile. Check Section 14 of the supplier's SDS.

How DOT hazard classes work →

15Regulatory information

• This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Bisphenol A is produced, as an intermediate or a final product, by process units covered under this subpart.
  Hazardous Substances Data Bank (HSDB)
• Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Bisphenol A is included on this list. Effective date 6/28/1984; Sunset date 6/28/1994.
  Hazardous Substances Data Bank (HSDB)
• 4,4'-Isopropylidenediphenol is an indirect food additive for use only as a component of adhesives.
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 6623 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.