1,3-Propanediol

1Identification

Name

1,3-Propanediol

IUPAC name

propane-1,3-diol

CAS number

504-63-2

EC number

207-997-3

Molecular formula

C3H8O2

Molecular weight

76.09 g/mol

InChIKey

YPFDHNVEDLHUCE-UHFFFAOYSA-N

SMILES

C(CO)CO

PubChem CID

10442

Synonyms

1,3-PROPANEDIOL, Propane-1,3-diol, Trimethylene glycol, 1,3-Dihydroxypropane, 1,3-Propylene glycol, 2-Deoxyglycerol, 1,3-Propylenediol, beta-Propylene glycol, 2-(Hydroxymethyl)ethanol, omega-Propanediol, RefChem:906914, 1,3-PROPANDIOL, .beta.-Propylene glycol, .omega.-Propanediol

Recommended uses

• Used as an intermediate in the production of polyesters; [Hawley]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• 1,3-Propanediol /PDO/ is mainly used for making polytrimethylene terephthalate polymer, which is used in fibers and fabrics, for example, carpets, textiles, engineering thermoplastics, nonwovens, films, and monofilaments. PDO finds also use as chain extender in thermoplastic polyurethanes, where it contributes to improved thermal, hydrolytic and dimensional stability. In adipate polyesters with other diols these diols are partly substituted by 1,3-propanediol to break crystallinity in order to obtain liquid polyester polyols. In polyesters for powder coatings PDO improves the flexibility but lowers the glass transition temperature somewhat.
  Hazardous Substances Data Bank (HSDB)
• Industrial uses: functional fluids (open system); intermediates; solvents (for cleaning or degreasing); solvents (which become part of product formulation or mixture) Consumer uses: anti-freeze and de-icing products; apparel and footwear care products; building/construction materials; floor coverings; ink, toner and colorant products; laundry and dishwashing products; personal care products
  Hazardous Substances Data Bank (HSDB)
• Polymerization promoter
  EPA Chemical Data Reporting (CDR)

Use categories: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers;Solvents · Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern · Fragrance Ingredients

Description

• Propane-1,3-diol is the simplest member of the class of propane-1,3-diols, consisting of propane in which one hydrogen from each methyl group is substituted by a hydroxy group. A colourless, viscous, water-miscible liquid with a high (210C) boiling point, it is used in the synthesis of certain polymers and as a solvent and antifreeze. It has a role as a metabolite and a protic solvent.
  ChEBI
• 1,3-propanediol has been reported in Solanum lycopersicum with data available.
  LOTUS - the natural products occurrence database
• 1,3-propanediol is a metabolite found in or produced by Saccharomyces cerevisiae.
  Yeast Metabolome Database (YMDB)

2Hazard identification

Signal word

Warning

Pictograms

GHS07

Classification source

Hazardous Substances Data Bank (HSDB)

Precautionary statements

NFPA 704 rating

• 1 - Materials that, under emergency conditions, can cause significant irritation.
  Hazardous Substances Data Bank (HSDB)
• 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.
  Hazardous Substances Data Bank (HSDB)
• 0 - Materials that in themselves are normally stable, even under fire conditions.
  Hazardous Substances Data Bank (HSDB)

Hazards summary

• A moderate human skin irritant; Causes somnolence in oral lethal-dose studies of cats and rats; [RTECS] May cause irritation; [Alfa Aesar MSDS]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

Not available in the public sources we compile. Check Section 4 of the supplier's SDS.

5Fire-fighting measures

• Extinguishing method: alcohol resistant fire fighting foam.
  Hazardous Substances Data Bank (HSDB)
• Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.
  Hazardous Substances Data Bank (HSDB)

Hazardous combustion products

• Special hazards arising from the substance or mixture: Carbon oxides
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Spill cleanup

• Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
  Hazardous Substances Data Bank (HSDB)

7Handling and storage

• Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
  Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

No occupational exposure limits found in our sources.

Personal protective equipment

• Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate, use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
  Hazardous Substances Data Bank (HSDB)
• Body Protection: Impervious clothing. the type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
  Hazardous Substances Data Bank (HSDB)
• Skin protection: Handle with gloves.
  Hazardous Substances Data Bank (HSDB)
• Eye/face protection: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
  Hazardous Substances Data Bank (HSDB)

9Physical and chemical properties

10Stability and reactivity

Incompatible materials and hazardous reactions

• Incompatible materials: Acid chlorides, Acid anhydrides, Oxidizing agents, Chloroformates, Reducing agents.
  Hazardous Substances Data Bank (HSDB)

Chemical stability

• Chemical stability: Stable under recommended storage conditions.
  Hazardous Substances Data Bank (HSDB)

11Toxicological information

Not available in the public sources we compile. Check Section 11 of the supplier's SDS.

12Ecological information

Environmental fate

• 1,3-Propanediol's production and use as an anti-freeze and de-icing product; in building materials (including floor coverings); apparel and footwear care products; ink, toner and colorant products; laundry and dishwashing products; and personal care products may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 0.044 mm Hg at 25 °C indicates 1,3-propanediol will exist solely as a vapor in the atmosphere. Vapor-phase 1,3-propanediol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 40 hours.
  Hazardous Substances Data Bank (HSDB)

Ecotoxicity

• EC50; Species: Daphnia magna (Water Flea) age 6-24 hr; Conditions: freshwater, static, 20 °C, pH > or =7.0; Concentration: 8285000 ug/L for 24 hr (95% confidence interval: 7357000-9331000 ug/L); Effect: intoxication, immobilization /formulated product/
  Hazardous Substances Data Bank (HSDB)
• LC50; Species: Carassius auratus (Goldfish) weight 3.3 g; Conditions: freshwater, static, 20 °C, pH 7.0, dissolved oxygen >4.0 mg/L; Concentration: >5000000 ug/L for 48 hr /formulated product/
  Hazardous Substances Data Bank (HSDB)

13Disposal considerations

• SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
  Hazardous Substances Data Bank (HSDB)
• Product: Contact a licensed professional waste disposal service to dispose of this material. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging: Dispose of as unused product.
  Hazardous Substances Data Bank (HSDB)

14Transport information

Not available in the public sources we compile. Check Section 14 of the supplier's SDS.

How DOT hazard classes work →

15Regulatory information

• Residues of 1,3-propanediol are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: Solvent, co-solvent, diluent, or freeze-point depressant.
  Hazardous Substances Data Bank (HSDB)
• Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. (a) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. 1,3-Propanediol is included on this list. Limits: None.
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 10442 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.