Dipropylene Glycol

1Identification

Name

Dipropylene Glycol

IUPAC name

2-(1-hydroxypropan-2-yloxy)propan-1-ol;1-(2-hydroxypropoxy)propan-2-ol

CAS number

25265-71-8 (also reported: 110-98-5)

EC number

246-770-3

Molecular formula

C12H28O6

Molecular weight

268.35 g/mol

InChIKey

BPRJQFIHEGORJE-UHFFFAOYSA-N

SMILES

CC(CO)OC(C)CO.CC(COCC(C)O)O

PubChem CID

134692469

Synonyms

Dipropylenglykol, 4-Oxa-2,6-heptandiol, RefChem:57330, Abelia seaweed refining mask, Abelia green tea energy mask, Abelia cucumber soothing mask, Abelia lemon brightening mask, Abelia collagen amplifying mask, Professional Level Brighting Pen, Abelia pomegranate bounce up mask, Abelia royal jelly nutrition mask, Abelia aloe vera moisturizing mask, Dipropylene Glycol, Dipropyleneglycol

Recommended uses

• CIR ingredient: Dipropylene Glycol
  Cosmetic Ingredient Review (CIR)
• Used in antifreeze, air sanitizers, cosmetic stabilizers, polyester and alkyd resins, reinforced plastics, plasticizers, solvents, and steam set printing inks; [HSDB] Used in hydraulic break fluids, cutting oils, textile lubricants, industrial soaps, pesticide solvents, fragrances, skin care products, deodorants, hair care products, shaving products, facial makeup, and bath and shower products; [CHEMINFO]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Metal Machining [Category: Heat or Machine] Painting (Pigments, Binders, and Biocides) [Category: Paint] Dressing Hair [Category: Other]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Wrinkle resisting agent Monomers Other Solvent Dispersing agent Anti-freeze agent Surface modifier Humectant Dye Intermediate Waterproofing agent Not Known or Reasonably Ascertainable Diluent Fragrance Plasticizer
  EPA Chemical Data Reporting (CDR)
• Solubility enhancer Monomers Solvent Anti-freeze agent Other Lubricating agent Intermediate Dye Fragrance Cleaning agent Not Known or Reasonably Ascertainable Viscosity modifiers
  EPA Chemical Data Reporting (CDR)

Use categories: EPA Safer Chemical Functional Use Classes -> Solvents · Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern · Fragrance Ingredients · Food Additives -> CARRIER_SOLVENT -> JECFA Functional Classes

Description

• Thick odorless, colorless liquid. Sinks and mixes with water. (USCG, 1999)
  CAMEO Chemicals

2Hazard identification

Signal word

Danger

Pictograms

GHS05, GHS07

Classification source

Hazardous Substances Data Bank (HSDB)

Precautionary statements

NFPA 704 rating

• 1 - Materials that, under emergency conditions, can cause significant irritation.
  Hazardous Substances Data Bank (HSDB)
• 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.
  Hazardous Substances Data Bank (HSDB)
• 0 - Materials that in themselves are normally stable, even under fire conditions.
  Hazardous Substances Data Bank (HSDB)

Health hazards

• Minor eye irritation (USCG, 1999)
  CAMEO Chemicals

Fire hazards

• This chemical is combustible. (NTP, 1992)
  CAMEO Chemicals
• Combustible.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Hazards summary

• Readily absorbed by GI tract and metabolically converted into propylene glycol; No deaths in animals inhaling 6-8 g/m3; 30% of rats exposed to 10% DPG in drinking water have kidney lesions; No fetal toxicity or teratogenicity in rats; [OECD SIDS: Dipropylene glycol (mixed isomers and dominant isomer) - 2001] May cause minor eye irritation; [CAMEO] Commercial dipropylene glycol (CAS # 25265-71-8) is composed of 3 isomers: (2,2' -dihydroxydiisopropropylether (CAS # 108-61-2); 2,2' -dihydroxydipropylether (CAS # 110-98-5); 2-hydroxypropyl-2'-hydroxyisopropylether (CAS # 106-62-7);
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

• EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
  CAMEO Chemicals

Symptoms of exposure

• Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

• Wear self contained breathing apparatus for fire fighting if necessary.
  Hazardous Substances Data Bank (HSDB)
• Use water spray, alcohol - resistant foam, dry chemical or carbon dioxide.
  Hazardous Substances Data Bank (HSDB)

Hazardous combustion products

• Hazardous decomposition products formed under fire conditions. - Carbon oxides
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Spill cleanup

• Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Avoid breathing vapours, mist or gas. ... Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Keep in suitable, closed containers for disposal.
  Hazardous Substances Data Bank (HSDB)

7Handling and storage

• Well closed.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Hygroscopic. Store under inert gas.
  Hazardous Substances Data Bank (HSDB)
• Keep container tightly closed in a dry and well - ventilated place.
  Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

No occupational exposure limits found in our sources.

Personal protective equipment

• Safety glasses with side shields or goggles; shower and eye bath. (USCG, 1999)
  CAMEO Chemicals
• impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
  Hazardous Substances Data Bank (HSDB)
• Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
  Hazardous Substances Data Bank (HSDB)
• Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with app licable laws and good laboratory practices. Wash and dry hands.
  Hazardous Substances Data Bank (HSDB)

9Physical and chemical properties

10Stability and reactivity

Reactivity

• DIPROPYLENE GLYCOL can react vigorously with acids and oxidizing materials. It is incompatible with strong bases. It is incompatible with peroxides. (NTP, 1992)
  CAMEO Chemicals
• This chemical is hygroscopic. Water soluble.
  CAMEO Chemicals

Incompatible materials and hazardous reactions

• Strong oxidizing agents
  Hazardous Substances Data Bank (HSDB)

Chemical stability

• Stable under recommended storage conditions.
  Hazardous Substances Data Bank (HSDB)

11Toxicological information

Routes of exposure

• The substance can be absorbed into the body by inhalation of its aerosol.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Short-term exposure effects

• The substance is mildly irritating to the eyes and skin.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Carcinogen classification

• Dipropylene Glycol
  NTP Technical Reports
• TR-511: Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (2004 )
  NTP Technical Reports
• 09/05/02
  NTP Technical Reports
• No Evidence
  NTP Technical Reports

12Ecological information

Environmental fate

• Dipropylene glycol's production and use as an intermediate for polyester and alkyd resins, reinforced plastics, plasticizers, and as a solvent may result in its direct release to the environment through various waste streams. Its use as an inert ingredient in pesticide formulations will result in its direct release to the environment. Commercial dipropylene glycol is composed of 3 isomers (2,2'-dihydroxydiisopropropylether, 2,2'-dihydroxydipropylether and 2-hydroxypropyl-2'-hydroxyisopropylether that have very similar values for relevant physical and environmental properties. This allows the commercial mixture to be evaluated as a discrete substance.
  Hazardous Substances Data Bank (HSDB)

Ecotoxicity

• LC50; Species: Rana brevipoda porosa (Daruma Pond frog); Conditions: static; Concentration: 5300 mg/L for 48 hr
  Hazardous Substances Data Bank (HSDB)
• LC50; Species: Xenopus laevis (African clawed frog); Conditions: static; Concentration: 3181 mg/L for 48 hr
  Hazardous Substances Data Bank (HSDB)
• LC50; Species: Carassius auratus (Goldfish); Conditions: static; Concentration: >5000 mg/L for 24 hr
  Hazardous Substances Data Bank (HSDB)

13Disposal considerations

• SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.
  Hazardous Substances Data Bank (HSDB)
• The following wastewater treatment technologies have been investigated for dipropylene glycol: Concentration process: Activated carbon.
  Hazardous Substances Data Bank (HSDB)
• Contaminated packaging: Dispose of as unused product.
  Hazardous Substances Data Bank (HSDB)

14Transport information

Not available in the public sources we compile. Check Section 14 of the supplier's SDS.

How DOT hazard classes work →

15Regulatory information

• This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Dipropylene glycol is produced, as an intermediate or a final product, by process units covered under this subpart.
  Hazardous Substances Data Bank (HSDB)
• Residues of dipropylene glycol are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: Solvent, cosolvent. Limit: None.
  Hazardous Substances Data Bank (HSDB)
• The Agency has completed its assessment of the dietary, drinking water, residential, ecological and occupational risks associated with the use of pesticide products containing the active ingredients propylene glycol and dipropylene glycol. Based on a review of these data, the Agency has sufficient information on the human health and ecological effects of propylene glycol and dipropylene glycol to make a decision as part of the tolerance reassessment process under FFDCA and reregistration under FIFRA, as amended by FQPA. The Agency has determined that propylene glycol and dipropylene glycol containing products are eligible for reregistration.
  Hazardous Substances Data Bank (HSDB)
• Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: 1/26/94; Reporting date: 3/28/94.
  Hazardous Substances Data Bank (HSDB)
• Dipropylene glycol is an indirect food additive for use only as a component of adhesives.
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 134692469 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.