2-Heptanone

1Identification

Name

2-Heptanone

IUPAC name

heptan-2-one

CAS number

110-43-0

EC number

203-767-1

Molecular formula

C7H14O

Molecular weight

114.19 g/mol

InChIKey

CATSNJVOTSVZJV-UHFFFAOYSA-N

SMILES

CCCCCC(=O)C

PubChem CID

8051

Synonyms

Heptan-2-one, Methyl pentyl ketone, Butylacetone, Amyl methyl ketone, Methyl amyl ketone, Methyl n-amyl ketone, n-Amyl methyl ketone, n-Pentyl methyl ketone, Pentyl methyl ketone, Methyl n-pentyl ketone, Ketone, methyl pentyl, Amyl-methyl-cetone, Methyl-amyl-cetone, Ketone C-7

Recommended uses

• Used as a solvent for resins and lacquers, a fragrance for cosmetics, and a flavor for foods; [HSDB]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Painting (Solvents) [Category: Paint] Plastic Composites Manufacturing [Category: Industry]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Industrial solvent; solvent for synthetic resin finishes; fragrance ingredient in creams, lotions, perfumes, soaps & detergents; flavor ingredient in foods; inert reaction medium
  Hazardous Substances Data Bank (HSDB)
• Solvent Other Fuel Cleaning agent Sealant (barrier) Not Known or Reasonably Ascertainable
  EPA Chemical Data Reporting (CDR)
• Solvent Sealant (barrier) Diluent Not Known or Reasonably Ascertainable
  EPA Chemical Data Reporting (CDR)

Use categories: Fragrance Ingredients · Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes · Flavoring Agents -> JECFA Flavorings Index

Description

• N-amyl methyl ketone appears as a clear colorless liquid. Flash point 126 °F. Less dense than water and only slightly soluble in water. Hence floats on water. Vapors heavier than air. Density 6.8 lb / gal. Used as a synthetic flavoring and in perfumes.
  CAMEO Chemicals
• Heptan-2-one is a dialkyl ketone with methyl and pentyl as the alkyl groups. It has a role as a pheromone and a mouse metabolite. It is a dialkyl ketone and a methyl ketone.
  ChEBI
• 2-Heptanone is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
  E. coli Metabolome Database (ECMDB)

2Hazard identification

Signal word

Warning

Pictograms

GHS02, GHS07

Classification source

Regulation (EC) No 1272/2008 of the European Parliament and of the Council

Precautionary statements

Other reported classifications

5 classification records exist across sources. Differences usually reflect purity, physical form or impurities.

NFPA 704 rating

• 1 - Materials that, under emergency conditions, can cause significant irritation.
  Hazardous Substances Data Bank (HSDB)
• 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.
  Hazardous Substances Data Bank (HSDB)
• 0 - Materials that in themselves are normally stable, even under fire conditions.
  Hazardous Substances Data Bank (HSDB)

Health hazards

• Inhalation can cause headache, fatigue, nausea, vomiting, dizziness, stupor, drowsiness, disturbed vision, and unconsciousness. Skin contact can cause moderate irritation, defatting, and dermatitis. Ingestion may cause irritation of lips and mouth, gastro-intestinal irritation, nausea, diarrhea, drowsiness, loss of consciousness, weak and rapid pulse, cold-pale complexion. (USCG, 1999)
  CAMEO Chemicals
• · Inhalation or contact with material may irritate or burn skin and eyes. · Fire may produce irritating, corrosive and/or toxic gases. · Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas. · Runoff from fire control or dilution water may cause environmental contamination.
  Emergency Response Guidebook (ERG)

Fire hazards

• Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon dioxide and carbon monoxide, may be formed when involved in fire. Behavior in Fire: Closed containers may explode when exposed to extreme heat. (USCG, 1999)
  CAMEO Chemicals
• · HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.) · Vapors may form explosive mixtures with air. · Vapors may travel to source of ignition and flash back. · Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). · Vapor explosion hazard indoors, outdoors or in sewers. · Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. · Runoff to sewer may create fire or explosion hazard.
  Emergency Response Guidebook (ERG)
• Flammable. Above 48 °C explosive vapour/air mixtures may be formed.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Hazards summary

• A potential CNS depressant after inhalation; [CAMEO]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

• Excerpt from NIOSH Pocket Guide for Methyl (n-amyl) ketone: Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: SOAP WASH - If this chemical contacts the skin, wash the contaminated skin with soap and water. Breathing: FRESH AIR - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. Other measures are usually unnecessary. Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)
  CAMEO Chemicals
• General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).
  Emergency Response Guidebook (ERG)
• (General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Soap wash - If this chemical contacts the skin, wash the contaminated skin with soap and water. Breathing: Fresh air Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
  The National Institute for Occupational Safety and Health (NIOSH)

Symptoms of exposure

• Cough. Dizziness. Headache. Unconsciousness. Blurred vision.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Dry skin. Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

• To fight fire, use foam, carbon dioxide, dry chemical.
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Isolation and evacuation

• Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
  CAMEO Chemicals
• Immediate precautionary measure · Isolate spill or leak area for at least 50 meters (150 feet) in all directions. Large Spill · Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire · If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
  Emergency Response Guidebook (ERG)

Spill cleanup

• Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable metal containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.
  ILO-WHO International Chemical Safety Cards (ICSCs)

7Handling and storage

• Fireproof.
  ILO-WHO International Chemical Safety Cards (ICSCs)

8Exposure controls / personal protection

Personal protective equipment

• Excerpt from NIOSH Pocket Guide for Methyl (n-amyl) ketone: Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact. Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact. Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated. Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)
  CAMEO Chemicals
• Wear appropriate personal protective clothing to prevent skin contact.
  Hazardous Substances Data Bank (HSDB)
• Wear appropriate eye protection to prevent eye contact.
  Hazardous Substances Data Bank (HSDB)
• Respirator Recommendations : Up to 800 ppm: (Assigned Protection Factor = 10) Any chemical cartridge respirator with organic vapor cartridge(s). Substance reported to cause eye irritation or damage; may require eye protection./(Assigned Protection Factor = 25) Any powered, air-purifying respirator with organic vapor cartridge(s). Substance reported to cause eye irritation or damage; may require eye protection./(Assigned Protection Factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister./(Assigned Protection Factor = 10) Any supplied-air respirator. Substance reported to cause eye irritation or damage;
  Hazardous Substances Data Bank (HSDB)

Respirator recommendations

• NIOSH/OSHA Up to 800 ppm: (APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)* (APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)* (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister (APF = 10) Any supplied-air respirator* (APF = 50) Any self-contained breathing apparatus with a full facepiece Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode (APF = 10,000) Any supplied-air respirator tha…
  The National Institute for Occupational Safety and Health (NIOSH)

9Physical and chemical properties

10Stability and reactivity

Reactivity

• N-AMYL METHYL KETONE reacts exothermically with many acids and bases to produce flammable gases (e.g., H2). The heat may be sufficient to start a fire in the unreacted portion. Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas and heat. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. Incompatible with many oxidizing agents including nitric acid, nitric acid/hydrogen peroxide mixture, and perchloric acid. May form peroxides (USCG, 1999).
  CAMEO Chemicals
• Flammable. Slightly soluble in water.
  CAMEO Chemicals

Incompatible materials and hazardous reactions

• Strong acids, alkalis, and oxidizers (Note: Will attack some forms of plastic).
  Hazardous Substances Data Bank (HSDB)
• Strong acids, alkalis & oxidizers [Note: Will attack some forms of plastic.]
  The National Institute for Occupational Safety and Health (NIOSH)

Chemical stability

• Low volatility
  Hazardous Substances Data Bank (HSDB)

11Toxicological information

Target organs

• Eyes, skin, respiratory system, central nervous system, peripheral nervous system
  The National Institute for Occupational Safety and Health (NIOSH)

Short-term exposure effects

• The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Long-term exposure effects

• The substance defats the skin, which may cause dryness or cracking.
  ILO-WHO International Chemical Safety Cards (ICSCs)

12Ecological information

Not available in the public sources we compile. Check Section 12 of the supplier's SDS.

13Disposal considerations

• SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
  Hazardous Substances Data Bank (HSDB)

14Transport information

UN number: UN 1110

Shipping name

• UN 1110; AMYL METHYL KETONE; METHYL AMYL KETONE
  Hazardous Substances Data Bank (HSDB)
• IMO 3.3; AMYL METHYL KETONE; METHYL AMYL KETONE
  Hazardous Substances Data Bank (HSDB)

DOT hazard class

• n-Amyl methyl ketone
  US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172
• UN1110
  US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172
• Class 3 Flammable and combustible liquid (49 eCFR § 173.120)
  US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172

DOT label

• Flammable Liquid
  CAMEO Chemicals

UN classification

• UN Hazard Class: 3; UN Pack Group: III
  ILO-WHO International Chemical Safety Cards (ICSCs)

Emergency Response Guidebook

• 1110 127
  Emergency Response Guidebook (ERG)

How DOT hazard classes work →

15Regulatory information

• Residues of 2-heptanone are exempted from the requirement of a tolerance when used as a solvent, co-solvent in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.
  Hazardous Substances Data Bank (HSDB)
• 2-Heptanone is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient. Synthetic flavoring substances and adjuvants /incl 2-Heptanone/ may be safely used in foods.
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 8051 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.