GHS precautionary statement
P381: In case of leakage, eliminate all ignition sources
- P381
- Response
P381 says: “In case of leakage, eliminate all ignition sources”. It is a response statement. P300 series: what to do after a spill, exposure or fire, including first-aid steps and when to call a poison center or doctor.
About the response group
P300 series: what to do after a spill, exposure or fire, including first-aid steps and when to call a poison center or doctor. See all precautionary statements for the full list.
Hazards that call for P381
The GHS data recommends P381 for these hazard statements.
| Code | Statement | Hazard class and category | Signal word |
|---|---|---|---|
| H220 | Extremely flammable gas | Flammable gases — 1A: Flammable gas, Pyrophoric gas, Chemically unstable gas A,B | Danger |
| H221 | Flammable gas | Flammable gases — 1B Flammable gases — Category 2 | Danger |
| H230 | May react explosively even in the absence of air | Flammable gases — 1A, Chemically unstable gas A | Danger |
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature | Flammable gases — 1A, Chemically unstable gas B | Danger |
| H232 | May ignite spontaneously if exposed to air | Flammable gases — 1A, Pyrophoric gas | Danger |
| H282 | Extremely flammable chemical under pressure: may explode if heated | Chemicals under pressure — Category 1 | Danger |
| H283 | Flammable chemical under pressure: may explode if heated | Chemicals under pressure — Category 2 | Warning |
Chemicals using P381
10 chemicals in our database. Classification comes from each chemical's primary GHS source, so a supplier's SDS may differ.
P381 frequently asked questions
What does P381 mean?
P381 says: "In case of leakage, eliminate all ignition sources". It is a response precautionary statement in the Response (P300 series).
Which hazards call for P381?
In the GHS data, P381 is recommended for hazard statements H220, H221, H230, H231, H232, H282, H283.
What type of statement is P381?
P381 is in the Response (P300 series). P300 series: what to do after a spill, exposure or fire, including first-aid steps and when to call a poison center or doctor.
Precautionary statements are general recommendations. Follow the specific instructions on your product's label and safety data sheet.
https://pubchem.ncbi.nlm.nih.gov/ghs/ghscode_10.txt (UN GHS Revision 10, retrieved 2026-10-12)