Glossary / Regulations
IARC
IARC is the International Agency for Research on Cancer, an arm of the World Health Organization that evaluates whether agents can cause cancer in humans. It sorts agents into groups 1, 2A, 2B, and 3 according to the strength of the evidence.
Explanation
IARC publishes its findings in a series called the Monographs. Expert working groups review the published studies on people, laboratory animals, and mechanisms, then assign each agent to a group. The monograph process is about whether an agent can cause cancer, not how likely it is under any particular exposure.
Group 1 means the agent is carcinogenic to humans. Group 2A means probably carcinogenic, Group 2B means possibly carcinogenic, and Group 3 means not classifiable as to carcinogenicity to humans. Group placement reflects the strength of the evidence, not the potency or size of the risk, which is why very different agents can share a group.
IARC is a hazard identification body, not a regulator. Its classifications inform other bodies. OSHA's HazCom rule requires Section 11 of the SDS to say whether a carcinogen is listed by IARC, the NTP Report on Carcinogens or OSHA, and a non-mandatory appendix explains how IARC and NTP findings relate to the GHS carcinogen categories.
On a safety data sheet, you may see IARC groupings in the toxicological section. Mixtures may carry a listing if an ingredient is listed. An IARC listing is not the same as a ban, and it does not tell you whether your exposure is meaningful.
Read the listing along with exposure information and the controls on the sheet.
What to do and watch for
- Note the IARC group for any ingredient flagged as a carcinogen.
- Do not equate group number with risk level; it reflects strength of evidence.
- Combine hazard listings with exposure data when assessing risk.
Where it appears on an SDS
- Section 11: Toxicological information. The toxicological section reports carcinogenicity listings, including the IARC group, for the product or its ingredients.
- Section 2: Hazard identification. A carcinogenicity classification may be reflected in the hazard identification section when criteria are met.
SDS content and wording vary by supplier. This page is general reference and does not replace the current SDS for your product.
Related terms
- Carcinogen
- National Toxicology Program (NTP)
- OSHA
- Hazard Communication Standard (HazCom)
- Mutagen
- Proposition 65