GHS precautionary statement

P221: Take any precaution to avoid mixing with combustibles/

P221
Prevention
Deleted

P221 was the precautionary statement “Take any precaution to avoid mixing with combustibles/”. It is marked as deleted in the GHS data we compile, so it is not part of the current GHS revision.

This code has been removed from GHS. You may still find it on older labels and SDSs. Our data does not say which code replaced it, so check the supplier's current SDS.

The dots (...) mark a blank that the supplier fills in with specific information, such as the equipment, material or temperature that applies to the product.

About the prevention group

P200 series: actions to take before and during use to prevent or minimise harm, such as avoiding ignition sources, using ventilation and wearing protective equipment. See all precautionary statements for the full list.

Hazards that call for P221

The GHS data we compile does not tie P221 to a specific hazard statement. Suppliers select it according to the product's classification and intended use.

Chemicals using P221

No chemicals in our database list P221 in their primary classification yet.

P221 frequently asked questions

Is P221 still used?

No. P221 ("Take any precaution to avoid mixing with combustibles/") is marked as deleted in the GHS data we compile, so it is not part of the current GHS revision. It may still appear on older labels and safety data sheets.

What did P221 say?

"Take any precaution to avoid mixing with combustibles/". It was a prevention precautionary statement.

Precautionary statements are general recommendations. Follow the specific instructions on your product's label and safety data sheet.

https://pubchem.ncbi.nlm.nih.gov/ghs/ghscode_10.txt (UN GHS Revision 10, retrieved 2026-10-12)