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GHS hazard statement

H281: Contains refrigerated gas; may cause cryogenic burns or injury

  • H281
  • Physical hazards
  • Warning

H281 means “Contains refrigerated gas; may cause cryogenic burns or injury”. It is a GHS hazard statement for Gases under pressure (Refrigerated liquefied gas), shown with GHS04 under the signal word “Warning”.

Hazard class and category

Hazard classCategoryPictogramSignal wordUN transport class
Gases under pressureRefrigerated liquefied gas
GHS pictogram GHS04: Gas Cylinder
WarningDiv 2.2

What H281 means

Gases under pressure are gases held in a receptacle at a pressure of 200 kPa (gauge) or more, or gases that are liquefied or liquefied and refrigerated. The GHS distinguishes compressed, liquefied, refrigerated liquefied and dissolved gases.

The cylinder or vessel can burst if it is heated. Refrigerated liquefied gases can also cause cryogenic burns or injury on contact.

What to do

Protect cylinders from sunlight and heat, keep them upright and secured, store in a well-ventilated place, and for refrigerated liquefied gases wear cold-insulating gloves and eye or face protection.

This is general guidance for the hazard class. The safety data sheet for your product always takes precedence.

Precautionary statements for H281

The GHS lists these precautionary statements for this hazard. Which ones appear on a label depends on the supplier's classification.

CodeStatement
P282Wear cold insulating gloves and either face shield or eye protection.
P336+P317Immediately thaw frosted parts with lukewarm water. Do not rub affected area. Get medical help.
P403Store in a well-ventilated place.

Chemicals carrying H281

4 chemicals in our database. Classification comes from each chemical's primary GHS source, so a supplier's SDS may differ.

H281 frequently asked questions

What does H281 mean?

H281 means "Contains refrigerated gas; may cause cryogenic burns or injury". It is a GHS hazard statement in the physical hazards group, covering Gases under pressure (Refrigerated liquefied gas).

Which pictogram goes with H281?

H281 is shown with GHS04 (Gas Cylinder).

What signal word goes with H281?

The signal word for H281 is "Warning".

Which precautionary statements go with H281?

The GHS data lists 3 precautionary statements for H281, including P282, P336+P317, P403. They cover prevention, response, storage and disposal. The full list is on this page.

Hazard statements describe the hazard of a classified substance or mixture. The classification of a specific product can differ, so use the supplier's SDS.

https://pubchem.ncbi.nlm.nih.gov/ghs/ghscode_10.txt (UN GHS Revision 10, retrieved 2026-10-12)