GHS hazard statement
H281: Contains refrigerated gas; may cause cryogenic burns or injury
- H281
- Physical hazards
- Warning
H281 means “Contains refrigerated gas; may cause cryogenic burns or injury”. It is a GHS hazard statement for Gases under pressure (Refrigerated liquefied gas), shown with GHS04 under the signal word “Warning”.
Hazard class and category
| Hazard class | Category | Pictogram | Signal word | UN transport class |
|---|---|---|---|---|
| Gases under pressure | Refrigerated liquefied gas | Warning | Div 2.2 |
What H281 means
Gases under pressure are gases held in a receptacle at a pressure of 200 kPa (gauge) or more, or gases that are liquefied or liquefied and refrigerated. The GHS distinguishes compressed, liquefied, refrigerated liquefied and dissolved gases.
The cylinder or vessel can burst if it is heated. Refrigerated liquefied gases can also cause cryogenic burns or injury on contact.
What to do
Protect cylinders from sunlight and heat, keep them upright and secured, store in a well-ventilated place, and for refrigerated liquefied gases wear cold-insulating gloves and eye or face protection.
This is general guidance for the hazard class. The safety data sheet for your product always takes precedence.
Precautionary statements for H281
The GHS lists these precautionary statements for this hazard. Which ones appear on a label depends on the supplier's classification.
Chemicals carrying H281
4 chemicals in our database. Classification comes from each chemical's primary GHS source, so a supplier's SDS may differ.
H281 frequently asked questions
What does H281 mean?
H281 means "Contains refrigerated gas; may cause cryogenic burns or injury". It is a GHS hazard statement in the physical hazards group, covering Gases under pressure (Refrigerated liquefied gas).
Which pictogram goes with H281?
H281 is shown with GHS04 (Gas Cylinder).
What signal word goes with H281?
The signal word for H281 is "Warning".
Which precautionary statements go with H281?
The GHS data lists 3 precautionary statements for H281, including P282, P336+P317, P403. They cover prevention, response, storage and disposal. The full list is on this page.
Hazard statements describe the hazard of a classified substance or mixture. The classification of a specific product can differ, so use the supplier's SDS.
https://pubchem.ncbi.nlm.nih.gov/ghs/ghscode_10.txt (UN GHS Revision 10, retrieved 2026-10-12)