1,6-Hexanediol

1Identification

Name

1,6-Hexanediol

IUPAC name

hexane-1,6-diol

CAS number

629-11-8 (also reported: 27236-13-1)

EC number

211-074-0

Molecular formula

C6H14O2

Molecular weight

118.17 g/mol

InChIKey

XXMIOPMDWAUFGU-UHFFFAOYSA-N

SMILES

C(CCCO)CCO

PubChem CID

12374

Synonyms

1,6-HEXANEDIOL, Hexane-1,6-diol, Hexamethylene glycol, 1,6-Dihydroxyhexane, Hexamethylenediol, alpha,omega-Hexanediol, hexamethyleneglycol, RefChem:907046, .alpha.,.omega.-Hexanediol, 6-hydroxy-1-hexanol, 1,6-Hexylene Glycol, HEZ, 1,6hexanediol, 1.6-hexanediol

Recommended uses

• Used as a solvent, an intermediate for nylon and polyesters, a coupling agent, a coal coating, a plasticizer, and in gasoline refining and the production of varnishes, adhesives, drugs, and textiles; [HSDB]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Textiles (Fiber & Fabric Manufacturing) [Category: Industry] Painting (Solvents) [Category: Paint] Working with Glues and Adhesives [Category: Other]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
• Solvent, intermediate for high polymers (nylon, polyesters), coupling agent, coil coating.
  Hazardous Substances Data Bank (HSDB)
• Other Solvent Not Known or Reasonably Ascertainable Intermediate
  EPA Chemical Data Reporting (CDR)
• Solvent Cleaning agent
  EPA Chemical Data Reporting (CDR)

Use categories: EPA Safer Chemical Functional Use Classes -> Solvents · Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Description

• Hexane-1,6-diol is a diol that is hexane substituted by hydroxy groups at positions 1 and 6. It is a primary alcohol and a diol. It derives from a hydride of a hexane.
  ChEBI
• Hexanediol is a metabolite found in or produced by Saccharomyces cerevisiae.
  Yeast Metabolome Database (YMDB)

2Hazard identification

Not available in the public sources we compile. Check Section 2 of the supplier's SDS.

Fire hazards

• Combustible. Finely dispersed particles form explosive mixtures in air.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Hazards summary

• An eye irritant; [ICSC]
  Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

Not available in the public sources we compile. Check Section 4 of the supplier's SDS.

Symptoms of exposure

• Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

• Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Hazardous Substances Data Bank (HSDB)
• Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
  Hazardous Substances Data Bank (HSDB)
• To fight fire, use foam, /carbon dioxide/, dry chemical
  Hazardous Substances Data Bank (HSDB)

Hazardous combustion products

• Special hazards arising from the substance or mixture: Carbon oxides.
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Spill cleanup

• Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Avoid breathing dust. Environmental precautions: No special environmental precautions required. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
  Hazardous Substances Data Bank (HSDB)
• Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
  Hazardous Substances Data Bank (HSDB)

7Handling and storage

• Separated from strong oxidants.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids.
  Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

No occupational exposure limits found in our sources.

Personal protective equipment

• Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
  Hazardous Substances Data Bank (HSDB)
• Skin protection: Handle with gloves.
  Hazardous Substances Data Bank (HSDB)
• Body Protection: Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place.
  Hazardous Substances Data Bank (HSDB)
• Respiratory protection: Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
  Hazardous Substances Data Bank (HSDB)

9Physical and chemical properties

10Stability and reactivity

Incompatible materials and hazardous reactions

• Incompatible materials: Acid chlorides, acid anhydrides, oxidizing agents, chloroformates, reducing agents.
  Hazardous Substances Data Bank (HSDB)
• Can react with oxidizing materials.
  Hazardous Substances Data Bank (HSDB)

Chemical stability

• Stable under recommended storage conditions.
  Hazardous Substances Data Bank (HSDB)

11Toxicological information

Routes of exposure

• The substance can be absorbed into the body by inhalation of its aerosol.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Short-term exposure effects

• The substance is irritating to the eyes.
  ILO-WHO International Chemical Safety Cards (ICSCs)

12Ecological information

Environmental fate

• 1,6-Hexanediol's production and use as an intermediate in the production of nylon, to make hexamethylenediamine, polyesters, polyurethans, in gasoline refining and as a plasticizer may result in its release to the environment through various waste streams. If released to air, an extrapolated vapor pressure of 5.0X10-4 mm Hg at 25 °C indicates 1,6-hexanediol will exist solely as a vapor in the atmosphere. Vapor-phase 1,6-hexanediol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 28 hrs.
  Hazardous Substances Data Bank (HSDB)

Ecotoxicity

• LC50; Species: Leuciscus idus (Ide); Conditions: static; Concentration: >1000 mg/L for 48 hr
  Hazardous Substances Data Bank (HSDB)
• EC50; Species: Daphnia magna (Water flea); Concentration: >500 mg/L for 24 and 48 hr; Effect: immobilization /Conditions of bioassay not specified in source examined/
  Hazardous Substances Data Bank (HSDB)
• EC50; Species: Scenedesmus subspicatus (Algae); Concentration: 2200 mg/L for 72 hr; Effect: growth inhibition, biomass /Conditions of bioassay not specified in source examined/
  Hazardous Substances Data Bank (HSDB)

13Disposal considerations

• SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
  Hazardous Substances Data Bank (HSDB)
• Product: Offer surplus and non-recyclable solutions to a licensed disposal company; Contaminated packaging: Dispose of as unused product.
  Hazardous Substances Data Bank (HSDB)

14Transport information

Not available in the public sources we compile. Check Section 14 of the supplier's SDS.

How DOT hazard classes work →

15Regulatory information

• This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Hexamethylene glycol is produced, as an intermediate or a final product, by process units covered under this subpart.
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 12374 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.